A New Workflow for Drug Metabolite Profiling by Utilizing Advanced Tribrid Mass Spectrometry and Data-Processing Techniques
Author:
Affiliation:
1. Non-clinical Disposition and Bioanalysis, BMS, Princeton, New Jersey 08540, United States
2. Thermo Fisher Scientific, San Jose, California 95134, United States
Publisher
American Chemical Society (ACS)
Subject
Spectroscopy,Structural Biology
Link
https://pubs.acs.org/doi/pdf/10.1021/jasms.0c00436
Reference25 articles.
1. Metabolite profiling: from diagnostics to systems biology
2. Metabolite structure analysis by high-resolution MS: supporting drug-development studies
3. Liquid chromatography–mass spectrometry based global metabolite profiling: A review
4. Reactive Metabolites in Early Drug Development: Predictive In vitro Tools
5. High-throughput quantitative and qualitative analysis of microsomal incubations by cocktail analysis with an ultraperformance liquid chromatography-quadrupole time-of-flight mass spectrometer system
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