Chemical metabolite synthesis and profiling: Mimicking in vivo biotransformation reactions

Author:

Chhatrapati Bisen Amol,Nashik Sanap Sachin,Agrawal Sristi,Biswas Arpon,Sankar Bhatta Rabi

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Molecular Biology,Biochemistry

Reference107 articles.

1. Effective application of metabolite profiling in drug design and discovery;Cerny;J. Med. Chem.,2020

2. Chapter Six - Biosynthesis using cytochrome P450 enzymes: Focus on synthesis of drug metabolites;Humphreys,2022

3. Non-clinical safety studies for the conduct of human clinical trials for pharmaceuticals: ICH M3 and M3 (R2), Global Approach in Safety Testing;Sjöberg;ICH Guidelines Explained,2013

4. US-FDA, Safety Testing of Drug Metabolites, in: C.f.D.E.a. Research (Ed.), U.S. Food and Drug Administration, USA, 2016.

5. The importance of drug metabolites synthesis: the case-study of cardiotoxic anticancer drugs;Hrynchak;Drug Metab. Rev.,2017

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