Binding Modes of Reverse Fosmidomycin Analogs toward the Antimalarial Target IspC-Reference-Cited by-同舟云学术

Binding Modes of Reverse Fosmidomycin Analogs toward the Antimalarial Target IspC

Published:2014-10-20 Issue:21 Volume:57 Page:8827-8838
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Konzuch Sarah¹,Umeda Tomonobu²,Held Jana³,Hähn Saskia¹,Brücher Karin¹,Lienau Claudia¹,Behrendt Christoph T.¹,Gräwert Tobias⁴,Bacher Adelbert⁴,Illarionov Boris⁴,Fischer Markus⁴,Mordmüller Benjamin³⁵,Tanaka Nobutada²,Kurz Thomas¹

Affiliation:

1. Institut für Pharmazeutische und Medizinische Chemie, Heinrich Heine Universität, Universitätsstr. 1, 40225 Düsseldorf, Germany

2. School of Pharmacy, Showa University, Tokyo 142-8555, Japan

3. Institut für Tropenmedizin, Eberhard Karls Universität Tübingen, Wilhelmstr. 27, 72074 Tübingen, Germany

4. Hamburg School of Food Science, Universität Hamburg, Grindelallee 117, 20146 Hamburg, Germany

5. Medical Research Unit, Albert Schweitzer Hospital, Lambaréné, Gabon

Funder

Deutsche Forschungsgemeinschaft

Ministry of Education, Culture, Sports, Science, and Technology

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm500850y

Reference43 articles.

1. World Malaria Report 2013;World Health Organization:Geneva, Switzerland, 2013.http://www.who.int/malaria/publications/world_malaria_report_2013/wmr2013_no_profiles.pdf?ua=1.

2. The MEP Pathway: A New Target for the Development of Herbicides, Antibiotics and Antimalarial Drugs

3. Artemisinin Resistance inPlasmodium falciparumMalaria

4. Studies on new phosphonic acid antibiotics. IV. Structure determination of FR-33289, FR-31564 and FR-32863.

5. E. coli MEP Synthase: Steady-State Kinetic Analysis and Substrate Binding

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