Reverse <i>N</i>-Substituted Hydroxamic Acid Derivatives of Fosmidomycin Target a Previously Unknown Subpocket of 1-Deoxy-<scp>d-</scp>xylulose 5-Phosphate Reductoisomerase (DXR)-Reference-Cited by-同舟云学术

Reverse N-Substituted Hydroxamic Acid Derivatives of Fosmidomycin Target a Previously Unknown Subpocket of 1-Deoxy-d-xylulose 5-Phosphate Reductoisomerase (DXR)

Published:2024-04-22 Issue:5 Volume:10 Page:1739-1752
ISSN:2373-8227
Container-title:ACS Infectious Diseases
language:en
Short-container-title:ACS Infect. Dis.

Author:

Abdullaziz Mona A.¹²,Takada Sana³^ORCID,Illarionov Boris⁴,Pessanha de Carvalho Lais⁵,Sakamoto Yasumitsu⁶,Höfmann Stefan¹^ORCID,Knak Talea¹,Kiffe-Delf Anna-Lene⁷,Mazzone Flaminia⁸^ORCID,Pfeffer Klaus⁸,Kalscheuer Rainer⁷^ORCID,Bacher Adelbert⁴⁹,Held Jana⁵¹⁰,Fischer Markus⁴,Tanaka Nobutada³^ORCID,Kurz Thomas¹^ORCID

Affiliation:

1. Heinrich Heine University Düsseldorf, Faculty of Mathematics and Natural Sciences, Institute of Pharmaceutical and Medicinal Chemistry, Universitätsstr. 1, 40225 Düsseldorf, Germany

2. National Research Centre (NRC), 33 El Buhouth St, Ad Doqi, Dokki, Cairo 12622, Egypt

3. School of Pharmacy, Kitasato University, Minato-ku, Tokyo 108-8641, Japan

4. Hamburg School of Food Science, Universität Hamburg, Grindelallee 117, 20146 Hamburg, Germany

5. Institut für Tropenmedizin, Eberhard Karls Universität Tübingen, Wilhelmstr. 27, 72074 Tübingen, Germany

6. School of Pharmacy, Iwate Medical University, Yahaba, Iwate 028-3694, Japan

7. Heinrich Heine University Düsseldorf, Faculty of Mathematics and Natural Sciences, Institute of Pharmaceutical Biology and Biotechnology, Universitätsstr. 1, 40225 Düsseldorf, Germany

8. Institute of Medical Microbiology and Hospital Hygiene, Heinrich Heine University, University Hospital Düsseldorf, Germany, 40225 Düsseldorf, Germany

9. TUM School of Natural Sciences, Technical University of Munich, Boltzmannstr. 10, 85748 Garching, Germany

10. German Center for Infection Research (DZIF), partner site Tübingen, 72074 Tübingen, Germany

Funder

Deutscher Akademischer Austauschdienst

Deutsche Forschungsgemeinschaft

Ministry of Higher Education and Scientific Research

Japan Society for the Promotion of Science

Heiwa Nakajima Foundation

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acsinfecdis.4c00100

Reference43 articles.

1. Malaria

2. Malaria − an overview

3. Malaria in 2022: Increasing challenges, cautious optimism

4. WHO World Malaria Report, 2022. (Accessed August 01, 2023).

5. Lubanga, B.; Chemtai, A.; Kwaro, D. The RTS,S/AS Malaria Vaccine Candidate: A Status Review. 2016; Vol. 2.