A Novel Crystallization-Induced Diastereomeric Transformation Based on a Reversible Carbon−Sulfur Bond Formation. Application to the Synthesis of a γ-Secretase Inhibitor-Reference-Cited by-同舟云学术

A Novel Crystallization-Induced Diastereomeric Transformation Based on a Reversible Carbon−Sulfur Bond Formation. Application to the Synthesis of a γ-Secretase Inhibitor

Published:2007-05-24 Issue:13 Volume:72 Page:4864-4871
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Davies Antony J.¹,Scott Jeremy P.¹,Bishop Brian C.¹,Brands Karel M. J.¹,Brewer Sarah E.¹,DaSilva Jimmy O.¹,Dormer Peter G.¹,Dolling Ulf-H.¹,Gibb Andrew D.¹,Hammond Deborah C.¹,Lieberman David R.¹,Palucki Michael¹,Payack Joseph F.¹

Affiliation:

1. Department of Process Research, Merck, Sharp & Dohme Research Laboratories, Hertford Road, Hoddesdon, Hertfordshire, EN11 9BU, United Kingdom, and Department of Process Research, Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/jo0705925

Reference48 articles.

1. Secretases as therapeutic targets in Alzheimer’s disease: patents 2000 – 2004

2. 2,3-Benzodiazepin-1,4-diones as peptidomimetic inhibitors of γ-secretase

3. A Practical Synthesis of a γ-Secretase Inhibitor

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