Synthesis of 3-Arylpiperazinylalkylpyrrolo[3,2-d]pyrimidine-2,4-dione Derivatives as Novel, Potent, and Selective α1-Adrenoceptor Ligands-Reference-Cited by-同舟云学术

Synthesis of 3-Arylpiperazinylalkylpyrrolo[3,2-d]pyrimidine-2,4-dione Derivatives as Novel, Potent, and Selective α1-Adrenoceptor Ligands

Published:2005-02-25 Issue:7 Volume:48 Page:2420-2431
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Patanè Emanuele¹,Pittalà Valeria¹,Guerrera Francesco¹,Salerno Loredana¹,Romeo Giuseppe¹,Siracusa Maria Angela¹,Russo Filippo¹,Manetti Fabrizio¹,Botta Maurizio¹,Mereghetti Ilario¹,Cagnotto Alfredo¹,Mennini Tiziana¹

Affiliation:

1. Dipartimento di Scienze Farmaceutiche, Università di Catania, viale A. Doria 6, 95125 Catania, Italy, Istituto di Ricerche Farmacologiche “Mario Negri”, via Eritrea 62, 20157 Milano, Italy, and Dipartimento Farmaco Chimico Tecnologico, Università degli Studi di Siena, via A. Moro, 53100 Siena, Italy

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm040870h

Reference40 articles.

1. .alpha.- and .beta.-Adrenoceptors: From the Gene to the Clinic. Part 1. Molecular Biology and Adrenoceptor Subclassification

2. .alpha.- and .beta.-Adrenoceptors: From the Gene to the Clinic. 2. Structure-Activity Relationships and Therapeutic Applications

3. A common step for signal transduction in G protein-coupled receptors

4. α1-Adrenoceptor subtypes

Cited by 30 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Evolving Novel Chemical Entities for Management of Benign Prostatic Hyperplasia#;Mini-Reviews in Medicinal Chemistry;2017-04-11

2. Synthesis and Experimental Validation of New Designed Heterocyclic Compounds with Antiproliferative Activity versus Breast Cancer Cell Lines MCF-7 and MDA-MB-231;Journal of Chemistry;2017

3. Methods for the synthesis of aza(deaza)xanthines as a basis of biologically active compounds;Russian Chemical Reviews;2016-03-31

4. Synthetic Entries to and Biological Activity of Pyrrolopyrimidines;Chemical Reviews;2015-12-23

5. Molecular pharmacophore selectivity studies, virtual screening, and in silico ADMET analysis of GPCR antagonists;Medicinal Chemistry Research;2015-07-14