Molecular pharmacophore selectivity studies, virtual screening, and in silico ADMET analysis of GPCR antagonists-Reference-Cited by-同舟云学术

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Molecular pharmacophore selectivity studies, virtual screening, and in silico ADMET analysis of GPCR antagonists

Published:2015-07-14 Issue:9 Volume:24 Page:3537-3550
ISSN:1054-2523
Container-title:Medicinal Chemistry Research
language:en
Short-container-title:Med Chem Res

Author:

Ahmed Hany Emary Ali,Zayed Mohamed F.,Ihmaid Saleh

Funder

Taibah University

Publisher

Springer Science and Business Media LLC

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics

Link

http://link.springer.com/content/pdf/10.1007/s00044-015-1389-6.pdf

Reference48 articles.

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2. Bender A, Glen C (2004) Molecular similarity: a key technique in molecular informatics. Org Biomol Chem 2:3204–3218

3. Betti L, Botta M, Corelli F, Floridi M, Giannaccini G, Maccari L, Manetti F, Strappaghetti G, Tafi A, Corsano S (2002) Alpha(1)-adrenoceptor antagonists—4: pharmacophore-based design, synthesis, and biological evaluation of new imidazo-, benzimidazo-, and indoloarylpiperazine derivatives. J Med Chem 45:3603–3611

4. Bettinetti L, Schlotter K, Hubner H, Gmeiner P (2002) Interactive SAR studies: rational discovery of super-potent and highly selective dopamine D3 receptor antagonists and partial agonists. J Med Chem 45:4594–4597

5. Bolognesi ML, Budriesi R, Chiarini A, Poggesi E, Leonardi A, Melchiorre C (1998) Design, synthesis, and biological activity of prazosin-related antagonists: role of the piperazine and furan units of prazosin on the selectivity for alpha1-adrenoreceptor subtypes. J Med Chem 41:4844–4853

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