Discovery of Selective and Orally Bioavailable Protein Kinase Cθ (PKCθ) Inhibitors from a Fragment Hit-Reference-Cited by-同舟云学术

Discovery of Selective and Orally Bioavailable Protein Kinase Cθ (PKCθ) Inhibitors from a Fragment Hit

Published:2014-07-07 Issue:1 Volume:58 Page:222-236
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

George Dawn M.¹,Breinlinger Eric C.¹,Friedman Michael¹,Zhang Yang²,Wang Jianfei²,Argiriadi Maria¹,Bansal-Pakala Pratima¹,Barth Martine³,Duignan David B.¹,Honore Prisca⁴,Lang QingYu⁵,Mittelstadt Scott⁴,Potin Dominique³,Rundell Lian¹,Edmunds Jeremy J.¹

Affiliation:

1. AbbVie Bioresearch Center, 381 Plantation Street, Worcester, Massachusetts 01605, United States

2. WuXi AppTec (Shanghai) Co., Ltd., 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, P. R. China

3. Inventiva, 50 Rue de Dijon, 21121 Daix, France

4. AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States

5. AbbVie China R&D Center, 5F, North Jin Chuang Building No. 1, 4560 Jinke Road, Pudong New District, Shanghai 201201, P. R. China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm500669m

Reference35 articles.

1. PKC and the control of localized signal dynamics

2. Defective IgG2a/2b Class Switching in PKCα−/− Mice

3. PKC-α regulates cardiac contractility and propensity toward heart failure

4. PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

5. Protein Kinase C θ Affects Ca2+ Mobilization and NFAT Activation in Primary Mouse T Cells

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