Design, synthesis, and antitumor efficacy of novel 5-deazaflavin derivatives backed by kinase screening, docking, and ADME studies-Reference-Cited by-同舟云学术

Design, synthesis, and antitumor efficacy of novel 5-deazaflavin derivatives backed by kinase screening, docking, and ADME studies

Published:2023-06-21 Issue:1 Volume:38 Page:
ISSN:1475-6366
Container-title:Journal of Enzyme Inhibition and Medicinal Chemistry
language:en
Short-container-title:Journal of Enzyme Inhibition and Medicinal Chemistry

Author:

Bedewy Walaa A.¹,Mohamed Mosaad S.²,Abdelhameed Ahmed M.¹,Elsawy Mohamed A.³⁴,Al-Muhur Mohammed⁵,Ashida Noriyuki⁶,Abdalla Ashraf N⁷,Elwaie Tamer A.⁸⁹,Nagamatsu Tomohisa¹⁰,Ali Hamed I.⁹

Affiliation:

1. Pharmaceutical Chemistry Department, Faculty of Pharmacy, Helwan University, Helwan, Egypt

2. Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Helwan University, Helwan, Egypt

3. Leicester Institute of Pharmaceutical Innovation, Leicester School of Pharmacy, De Monfort University, Leicester, UK

4. School of Pharmacy, Queen’s University of Belfast, Belfast, UK

5. Doctor Suliman Al Habib Hospital, Riyadh, Saudi Arabia

6. Biology Laboratory, Research and Development Division, Yamasa Co., Chiba, Japan

7. Department of Pharmacology and Toxicology, Pharmacy College, Umm Al-Qura University, Makkah, Saudi Arabia

8. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt

9. Department of Pharmaceutical Sciences, Irma Lerma Rangel School of Pharmacy, Texas A&M University, College Station, TX, USA

10. Faculty of Pharmacological Sciences, Laboratory of Curative Creation Study for Geriatric-diseases Prevention, Sojo University, Kumamoto, Japan

Funder

Institute of Scientific Research and Revival of Islamic Heritage, Umm Al-Qura University, Makkah, Saudi Arabia

Texas A&M Health Sciences Center

Publisher

Informa UK Limited

Subject

Drug Discovery,Pharmacology,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/14756366.2023.2220570

Reference76 articles.

1. Antitumor studies. Part 5: Synthesis, antitumor activity, and molecular docking study of 5-(monosubstituted amino)-2-deoxo-2-phenyl-5-deazaflavins

2. Antitumor studies. Part 1: Design, synthesis, antitumor activity, and AutoDock study of 2-deoxo-2-phenyl-5-deazaflavins and 2-deoxo-2-phenylflavin-5-oxides as a new class of antitumor agents

3. Antitumor studies. Part 3: Design, synthesis, antitumor activity, and molecular docking study of novel 2-methylthio-, 2-amino-, and 2-(N-substituted amino)-10-alkyl-2-deoxo-5-deazaflavins

4. Antitumor studies. Part 4: Design, synthesis, antitumor activity, and molecular docking study of novel 2-substituted 2-deoxoflavin-5-oxides, 2-deoxoalloxazine-5-oxides, and their 5-deaza analogs

5. Antitumor studies – Part 2: Structure–activity relationship study for flavin analogs including investigations on their in vitro antitumor assay and docking simulation into protein tyrosine kinase

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