1. Institute of Biotechnology, National Dong Hwa University, Hualien, 97401, Taiwan; Department of Molecular Biotechnology, Da-Yeh University, Changhua 51591, Taiwan; Department of Research, Buddhist Tzu Chi General Hospital, General Education Center, Tzu Chi College of Technology, 97002, Hualien, Taiwan; and Department of Biotechnology, National Formosa University, Yunlin 63208, Taiwan