Tuning the Sensitivity of Genetically Encoded Fluorescent Potassium Indicators through Structure-Guided and Genome Mining Strategies

Author:

Torres Cabán Cristina C.123,Yang Minghan4567,Lai Cuixin456,Yang Lina456,Subach Fedor V.8ORCID,Smith Brian O.9,Piatkevich Kiryl D.456ORCID,Boyden Edward S.1231011

Affiliation:

1. McGovern Institute for Brain Research, MIT, Cambridge, Massachusetts 02139, United States

2. Department of Biological Engineering, MIT, Cambridge, Massachusetts 02139, United States

3. Department of Media Arts & Sciences, MIT, Cambridge, Massachusetts 02139, United States

4. School of Life Sciences, Westlake University, Hangzhou, Zhejiang 310024, China

5. Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang 310024, China

6. Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Hangzhou, Zhejiang 310024, China

7. College of Physics, Jilin University, Changchun, Jilin 130012, China

8. Complex of NBICS Technologies, National Research Center “Kurchatov Institute”, Moscow 123182, Russia

9. Institute of Molecular, Cell & Systems Biology, College of Medical Veterinary & Life Sciences, University of Glasgow, Glasgow G128QQ, United Kingdom

10. Koch Institute for Integrative Cancer Research, MIT, Cambridge, Massachusetts 02139, United States

11. Howard Hughes Medical Institute, Chevy Chase, Maryland 20815, United States

Funder

Howard Hughes Medical Institute

National Institute of Neurological Disorders and Stroke

Division of Undergraduate Education

Alfred P. Sloan Foundation

Brain and Behavior Research Foundation

National Institute on Drug Abuse

National Institute of Mental Health

Division of Chemical, Bioengineering, Environmental, and Transport Systems

National Natural Science Foundation of China

National Institute of General Medical Sciences

National Science Foundation

National Research Center, Kurchatov Institute

Foundation of Westlake University

Publisher

American Chemical Society (ACS)

Subject

Fluid Flow and Transfer Processes,Process Chemistry and Technology,Instrumentation,Bioengineering

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