Structure−Activity Relationships of the Didemnins

Author:

Sakai Ryuichi1,Rinehart Kenneth L.1,Kishore Vimal1,Kundu Bijoy1,Faircloth Glynn1,Gloer James B.1,Carney John R.1,Namikoshi Michio1,Sun Furong1,Hughes, Robert G.1,Grávalos Dolores García1,de Quesada Teresa García1,Wilson George R.1,Heid Richard M.1

Affiliation:

1. Roger Adams Laboratory, University of Illinois, Urbana, Illinois 61801, Roswell Park Cancer Institute, Buffalo, New York 14263, PharmaMar, U.S.A., Inc., Cambridge, Massachusetts 02139, and PharmaMar, S.A., 28760 Tres Cantos (Madrid), Spain

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Reference57 articles.

1. Data in this paper are taken in part from the following:  Sakai, R. Biologically Active Compounds from Tunicates and a Sponge. Ph.D. Thesis, University of Illinois, Urbana, 1991.

2. Regioselectivity in the intramolecular ene reaction of cyclopropene derivatives

3. Didemnins: Antiviral and Antitumor Depsipeptides from a Caribbean Tunicate

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