1. Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan
2. Institute of Science and Engineering, Kanazawa University, Kakuma, Kanazawa, Ishikawa 920-1192, Japan
3. Laboratory for Computational Molecular Design, RIKEN Quantitative Biology Center, 6-2-4 Furuedai, Suita, Osaka 565-0874, Japan