1. Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada
2. Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada
3. Department of Mathematics & Statistics, Queen’s University, Kingston, Ontario K7L 3N6, Canada
4. Molecular Medicine, Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada