Molecular Mechanism of Inhibiting WNK Binding to OSR1 by Targeting the Allosteric Pocket of the OSR1-CCT Domain with Potential Antihypertensive Inhibitors: An In Silico Study-Reference-Cited by-同舟云学术

Molecular Mechanism of Inhibiting WNK Binding to OSR1 by Targeting the Allosteric Pocket of the OSR1-CCT Domain with Potential Antihypertensive Inhibitors: An In Silico Study

Published:2021-08-09 Issue:32 Volume:125 Page:9115-9129
ISSN:1520-6106
Container-title:The Journal of Physical Chemistry B
language:en
Short-container-title:J. Phys. Chem. B

Author:

Jonniya Nisha Amarnath¹^ORCID,Zhang Jinwei²,Kar Parimal¹^ORCID

Affiliation:

1. Department of Biosciences and Biomedical Engineering, Indian Institute of Technology Indore, Khandwa Road, Indore, Madhya Pradesh 453552, India

2. Institute of Biomedical and Clinical Sciences, College of Medicine and Health, University of Exeter Medical School, Hatherly Laboratories, Prince of Wales Road, Exeter EX4 4PS, U.K.

Funder

Royal Society

Department of Science and Technology, Ministry of Science and Technology

Publisher

American Chemical Society (ACS)

Subject

Materials Chemistry,Surfaces, Coatings and Films,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jpcb.1c04672

Reference69 articles.

1. Molecular Physiology and Pathophysiology of Electroneutral Cation-Chloride Cotransporters

2. The WNK-SPAK/OSR1 pathway: Master regulator of cation-chloride cotransporters