Identifying Key Residues That Drive Strong Electrostatic Attractions between Therapeutic Antibodies-Reference-Cited by-同舟云学术

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Identifying Key Residues That Drive Strong Electrostatic Attractions between Therapeutic Antibodies

Published:2019-11-18 Issue:50 Volume:123 Page:10642-10653
ISSN:1520-6106
Container-title:The Journal of Physical Chemistry B
language:en
Short-container-title:J. Phys. Chem. B

Author:

Ferreira Glenn M.¹,Shahfar Hassan¹²,Sathish Hasige A.³,Remmele Richard L.⁴,Roberts Christopher J.¹^ORCID

Affiliation:

1. Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, Delaware 19716, United States

2. Department of Physics and Astronomy, University of Delaware, Newark, Delaware 19716, United States

3. AstraZeneca, Gaithersburg, Maryland 20878, United States

4. RemSciBiothera, Inc., Camarillo, California 93012, United States

Funder

AstraZeneca

Publisher

American Chemical Society (ACS)

Subject

Materials Chemistry,Surfaces, Coatings and Films,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jpcb.9b08355

Reference56 articles.

1. Increase in Solubility of Monoclonal Antibodies - Formulation Perspective and the “Magic” of Arginine

2. Effects of Protein Conformation, Apparent Solubility, and Protein–Protein Interactions on the Rates and Mechanisms of Aggregation for an IgG1Monoclonal Antibody

3. Aggregates in monoclonal antibody manufacturing processes

4. Advances in Antibody Design

5. Solubility Challenges in High Concentration Monoclonal Antibody Formulations: Relationship with Amino Acid Sequence and Intermolecular Interactions

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1. Antibody association in solution: cluster distributions and mechanisms;mAbs;2024-04-26

2. Impact of Glycosylation on Protein–Protein Self-Interactions of Monoclonal Antibodies;Molecular Pharmaceutics;2024-02-22

3. Electrostatically Mediated Attractive Self-Interactions and Reversible Self-Association of Fc-Fusion Proteins;Molecular Pharmaceutics;2024-02-09

4. Computational Screening for mAb Colloidal Stability with Coarse-Grained, Molecular-Scale Simulations;The Journal of Physical Chemistry B;2024-02-05

5. The Relationship between Protein–Protein Interactions and Liquid–Liquid Phase Separation for Monoclonal Antibodies;Molecular Pharmaceutics;2023-04-11

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