RASP: Optimal Single Puncta Detection in Complex Cellular Backgrounds

Author:

Fu Bin12ORCID,Brock Emma E.12,Andrews Rebecca12,Breiter Jonathan C.123,Tian Ru123,Toomey Christina E.245,Lachica Joanne246ORCID,Lashley Tammaryn245,Ryten Mina2789,Wood Nicholas W.210,Vendruscolo Michele23ORCID,Gandhi Sonia2106,Weiss Lucien E.11,Beckwith Joseph S.12ORCID,Lee Steven F.12ORCID

Affiliation:

1. Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, U.K.

2. Aligning Science Across Parkinson’s (ASAP) Collaborative Research Network, Chevy Chase, Maryland 20815, United States

3. Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K.

4. The Queen Square Brain Bank for Neurological Disorders, Department of Clinical and Movement Neuroscience, UCL Queen Square Institute of Neurology, London WC1N 3BG, U.K.

5. Department of Neurodegenerative Diseases, UCL Queen Square Institute of Neurology, London WC1N 3BG, U.K.

6. The Francis Crick Institute, King’s Cross, London NW1 1AT, U.K.

7. Great Ormond Street Institute of Child Health, University College London, London WC1E 6BT, U.K.

8. UK Dementia Research Institute at the University of Cambridge, Cambridge CB2 0AH, U.K.

9. Department of Clinical Neurosciences, School of Clinical Medicine, University of Cambridge, Cambridge CB2 0SP, U.K.

10. Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London WC1N 3BG, U.K.

11. Department of Engineering Physics, Polytechnique Montréal, Montréal, Québec H3T 1J4, Canada

Funder

Aligning Science Across Parkinson's

Government of Canada

Publisher

American Chemical Society (ACS)

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