Role of Domain–Domain Interactions on the Self-Association and Physical Stability of Monoclonal Antibodies: Effect of pH and Salt-Reference-Cited by-同舟云学术

Role of Domain–Domain Interactions on the Self-Association and Physical Stability of Monoclonal Antibodies: Effect of pH and Salt

Published:2023-09-26 Issue:39 Volume:127 Page:8344-8357
ISSN:1520-6106
Container-title:The Journal of Physical Chemistry B
language:en
Short-container-title:J. Phys. Chem. B

Author:

Xu Amy Y.¹^ORCID,Blanco Marco A.²,Castellanos Maria Monica³⁴^ORCID,Meuse Curtis W.³⁵^ORCID,Mattison Kevin⁶,Karageorgos Ioannis³⁵,Hatch Harold W.⁷^ORCID,Shen Vincent K.⁷,Curtis Joseph E.⁴^ORCID

Affiliation:

1. Department of Chemistry, Louisiana State University, Baton Rouge, Louisiana 70803, United States

2. Discovery Pharmaceutical Sciences, Merck Research Laboratories, Merck & Co., Inc, West Point, Pennsylvania 19486, United States

3. Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, Maryland 20850, United States

4. NIST Center for Neutron Research, National Institute of Standards and Technology, Gaithersburg, Maryland 20899, United States

5. Biomolecular Measurement Division, National Institute of Standards and Technology, Gaithersburg, Maryland 20899, United States

6. Malvern Panalytical, Westborough, Massachusetts 01581, United States

7. Chemical Sciences Division, Material Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, Maryland 20899, United States

Funder

Engineering and Physical Sciences Research Council

National Institute of Food and Agriculture

National Science Foundation

Publisher

American Chemical Society (ACS)

Subject

Materials Chemistry,Surfaces, Coatings and Films,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jpcb.3c03928

Reference65 articles.

1. Future perspectives of therapeutic monoclonal antibodies