Synthesis and Biological Evaluation of Thiol-Based Inhibitors of Glutamate Carboxypeptidase II: Discovery of an Orally Active GCP II Inhibitor-Reference-Cited by-同舟云学术

Synthesis and Biological Evaluation of Thiol-Based Inhibitors of Glutamate Carboxypeptidase II: Discovery of an Orally Active GCP II Inhibitor

Published:2003-04-02 Issue:10 Volume:46 Page:1989-1996
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Majer Pavel¹,Jackson Paul F.¹,Delahanty Greg¹,Grella Brian S.¹,Ko Yao-Sen¹,Li Weixing¹,Liu Qun¹,Maclin Keith M.¹,Poláková Jana¹,Shaffer Kathryn A¹,Stoermer Doris¹,Vitharana Dilrukshi¹,Wang Eric Yanjun¹,Zakrzewski Anthony¹,Rojas Camilo¹,Slusher Barbara S.¹,Wozniak Krystyna M.¹,Burak Eric¹,Limsakun Tharin¹,Tsukamoto Takashi¹

Affiliation:

1. Guilford Pharmaceuticals Inc., 6611 Tributary Street, Baltimore, Maryland 21224

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm020515w

Reference32 articles.

1. l-Glutamate as a Central Neurotransmitter: Looking Back

2. Amino acids are still as exciting as ever

3. Carter, R. E.; Coyle, J. T. Glutamate Carboxypeptidase II.Handbook ofProteolytic Enzymes; Academic: New York, 1998; pp 1434−1437.

4. Current approaches to multiple parallel synthesis

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