Affiliation:
1. Affiliated Hospital of Guangdong Medical University (GDMU) Zhanjiang Guangdong 524000 P.R. China
2. The Institute of Pharmacology School of Basic Medical Sciences Lanzhou University Lanzhou 730000 P.R. China
3. The Second Clinical Medical College Lanzhou University Lanzhou Gansu 730000 P.R. China
Abstract
AbstractOptical pharmaceutical important compounds which bring CF2H to mimic the role of –SH were synthesized through the asymmetric S‐Michael addition reaction in the presence of quinine–a derived squaramide catalyst. Various sulfhydryl compounds including Benzyl mercaptan, phenthiol, alkyl thiophenol, mercaptoacetate, methyl 3‐mercaptoacrylate, and 1,4‐dithiane‐2,5‐diol were tested. The broad substrate scope, good functional group tolerance, and easy derivatization make this synthesis method very attractive.
Funder
National Natural Science Foundation of China
Subject
Organic Chemistry,Physical and Theoretical Chemistry