A Novel Class of Oral Direct Renin Inhibitors: Highly Potent 3,5-Disubstituted Piperidines Bearing a Tricyclic P3–P1 Pharmacophore-Reference-Cited by-同舟云学术

A Novel Class of Oral Direct Renin Inhibitors: Highly Potent 3,5-Disubstituted Piperidines Bearing a Tricyclic P3–P1 Pharmacophore

Published:2013-03-15 Issue:6 Volume:56 Page:2196-2206
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Ostermann Nils¹,Ruedisser Simon¹,Ehrhardt Claus¹,Breitenstein Werner¹,Marzinzik Andreas¹,Jacoby Edgar¹,Vangrevelinghe Eric¹,Ottl Johannes¹,Klumpp Martin¹,Hartwieg J. Constanze D.¹,Cumin Frederic¹,Hassiepen Ulrich¹,Trappe Jörg¹,Sedrani Richard¹,Geisse Sabine¹,Gerhartz Bernd¹,Richert Paul¹,Francotte Eric¹,Wagner Trixie¹,Krömer Markus¹,Kosaka Takatoshi²,Webb Randy L.³,Rigel Dean F.³,Maibaum Jürgen¹,Baeschlin Daniel K.¹

Affiliation:

1. Novartis Pharma AG, Institutes for BioMedical Research, Novartis Campus, CH-4056 Basel, Switzerland

2. Novartis Institutes for BioMedical Research, Horsham, West Sussex RH12 5AB, U.K.

3. Novartis Pharmaceuticals Corp., Novartis Institutes for BioMedical Research, East Hanover, New Jersey, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm301706j

Reference25 articles.

1. Global burden of hypertension: analysis of worldwide data