Tumor-Targeting with Novel Non-Benzoyl 6-Substituted Straight Chain Pyrrolo[2,3-d]pyrimidine Antifolates via Cellular Uptake by Folate Receptor α and Inhibition of de Novo Purine Nucleotide Biosynthesis-Reference-Cited by-同舟云学术

Tumor-Targeting with Novel Non-Benzoyl 6-Substituted Straight Chain Pyrrolo[2,3-d]pyrimidine Antifolates via Cellular Uptake by Folate Receptor α and Inhibition of de Novo Purine Nucleotide Biosynthesis

Published:2013-10-30 Issue:21 Volume:56 Page:8684-8695
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Wang Yiqiang¹,Cherian Christina²³,Orr Steven²³,Mitchell-Ryan Shermaine³,Hou Zhanjun²³,Raghavan Sudhir¹,Matherly Larry H.²³⁴,Gangjee Aleem¹

Affiliation:

1. Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, Pennsylvania 15282, United States

2. Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, 110 East Warren Avenue, Detroit, Michigan 48201, United States

3. Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan 48201, United States

4. Department of Pharmacology, Wayne State University School of Medicine, Detroit, Michigan 48201, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm401139z

Reference27 articles.

1. Human reduced folate carrier: translation of basic biology to cancer etiology and therapy

2. Distribution, functionality and gene regulation of folate receptor isoforms: implications in targeted therapy

3. Folate-Linked Drugs for the Treatment of Cancer and Inflammatory Diseases

4. Membrane transporters and folate homeostasis: intestinal absorption and transport into systemic compartments and tissues

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