Metabolism of Sirolimus and Its Derivative Everolimus by Cytochrome P450 3A4: Insights from Docking, Molecular Dynamics, and Quantum Chemical Calculations-Reference-Cited by-同舟云学术

Metabolism of Sirolimus and Its Derivative Everolimus by Cytochrome P450 3A4: Insights from Docking, Molecular Dynamics, and Quantum Chemical Calculations

Published:2001-05-11 Issue:12 Volume:44 Page:2027-2034
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kuhn Bernd¹,Jacobsen Wolfgang¹,Christians Uwe¹,Benet Leslie Z.¹,Kollman Peter A.¹

Affiliation:

1. Department of Pharmaceutical Chemistry and Department of Biopharmaceutical Sciences, University of California at San Francisco, San Francisco, California 94143-0446

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm010079y

Reference40 articles.

1. Rapamune (Sirolimus, Rapamycin): An Overview and Mechanism of Action

2. Newer Immunosuppressive Drugs

3. Chemical modification of rapamycin: the discovery of SDZ RAD

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