A New Class of Antimalarial Dioxanes Obtained through a Simple Two-Step Synthetic Approach: Rational Design and Structure–Activity Relationship Studies-Reference-Cited by-同舟云学术

A New Class of Antimalarial Dioxanes Obtained through a Simple Two-Step Synthetic Approach: Rational Design and Structure–Activity Relationship Studies

Published:2011-11-23 Issue:24 Volume:54 Page:8526-8540
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Persico Marco¹²,Quintavalla Arianna³,Rondinelli Francesca¹²,Trombini Claudio³,Lombardo Marco³,Fattorusso Caterina¹²,Azzarito Valeria⁴,Taramelli Donatella⁵²,Parapini Silvia⁵²,Corbett Yolanda⁵²,Chianese Giuseppina¹²,Fattorusso Ernesto¹²,Taglialatela-Scafati Orazio¹²

Affiliation:

1. Dipartimento di Chimica delle Sostanze Naturali, Università di Napoli “Federico II”, Via D. Montesano, 49 I-80131 Napoli, Italy

2. Italian Malaria Network - Centro Interuniversitario di Ricerche sulla Malaria (CIRM), Dipartimento di Genetica, Biologia e Biochimica, Università di Torino, via Santena 19, I-10126 Torino, Italy

3. Dipartimento di Chimica “Giacomo Ciamician”, Alma Mater Studiorum, Università di Bologna, Via Selmi, 2 I-40126 Bologna, Italy

4. School of Chemistry, University of Leeds, Woodhouse Lane, Leeds, LS29JT, U.K.

5. Dipartimento di Sanità Pubblica, Microbiologia, Virologia, Università di Milano, Via Pascal 36, I-20133 Milano, Italy

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm201056j

Reference71 articles.

1. A call for using natural compounds in the development of new antimalarial treatments – an introduction

2. MOLECULAR MECHANISMS OF RESISTANCE IN ANTIMALARIAL CHEMOTHERAPY: The Unmet Challenge