Synthesis of Enantiopure Piperazines via Asymmetric Lithiation–Trapping of N-Boc Piperazines: Unexpected Role of the Electrophile and Distal N-Substituent-Reference-Cited by-同舟云学术

Synthesis of Enantiopure Piperazines via Asymmetric Lithiation–Trapping of N-Boc Piperazines: Unexpected Role of the Electrophile and Distal N-Substituent

Published:2015-12-31 Issue:2 Volume:138 Page:651-659
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Firth James D.¹,O’Brien Peter¹,Ferris Leigh²

Affiliation:

1. Department of Chemistry, University of York, Heslington, York YO10 5DD, U.K.

2. AstraZeneca U.K., Macclesfield, Cheshire SK10 2NA, U.K.

Funder

AstraZeneca

Engineering and Physical Sciences Research Council

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.5b11288

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5. Pyridonecarboxylic acids as antibacterial agents. Part 14. Synthesis and structure-activity relationships of 5-substituted 6,8-difluoroquinolones, including sparfloxacin, a new quinolone antibacterial agent with improved potency

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