Exploring Gatekeeper Mutations in EGFR through Computer Simulations-Reference-Cited by-同舟云学术

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Exploring Gatekeeper Mutations in EGFR through Computer Simulations

Published:2019-05-17 Issue:6 Volume:59 Page:2850-2858
ISSN:1549-9596
Container-title:Journal of Chemical Information and Modeling
language:en
Short-container-title:J. Chem. Inf. Model.

Author:

Kannan Srinivasaraghavan¹^ORCID,Fox Stephen J.¹,Verma Chandra S.¹²³^ORCID

Affiliation:

1. Bioinformatics Institute, Agency for Science Technology and Research (A*STAR), 30 Biopolis Street, #07-01 Matrix, Singapore 138671 Singapore

2. School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore

3. Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543, Singapore

Funder

Agency for Science, Technology and Research

Publisher

American Chemical Society (ACS)

Subject

Library and Information Sciences,Computer Science Applications,General Chemical Engineering,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.9b00361

Reference59 articles.

1. A comprehensive map of molecular drug targets

2. Ten things you should know about protein kinases: IUPHAR Review 14

3. 25 Years of Small Molecular Weight Kinase Inhibitors: Potentials and Limitations

4. A historical overview of protein kinases and their targeted small molecule inhibitors

5. The target landscape of clinical kinase drugs

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2. Case Report: A patient with the rare third-generation TKI-resistant mutation EGFR L718Q who responded to afatinib plus cetuximab combination therapy;Frontiers in Oncology;2022-10-31

3. Structural dynamics and kinase inhibitory activity of three generations of tyrosine kinase inhibitors against wild-type, L858R/T790M, and L858R/T790M/C797S forms of EGFR;Computers in Biology and Medicine;2022-08

4. “Sandwich” Strategy to Intensify EGFR Blockade by Concurrent Tyrosine Kinase Inhibitor and Monoclonal Antibody Treatment in Highly Selected Patients;Frontiers in Oncology;2022-07-08

5. Identification of a Rare EGFR T790I Mutation in Lung Adenocarcinoma Sensitive to Osimertinib;Frontiers in Oncology;2021-10-20

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