Discovery of P2Y<sub>2</sub> Receptor Antagonist Scaffolds through Virtual High-Throughput Screening-Reference-Cited by-同舟云学术

Discovery of P2Y₂ Receptor Antagonist Scaffolds through Virtual High-Throughput Screening

Published:2022-03-14 Issue:6 Volume:62 Page:1538-1549
ISSN:1549-9596
Container-title:Journal of Chemical Information and Modeling
language:en
Short-container-title:J. Chem. Inf. Model.

Author:

Neumann Alexander¹²,Attah Isaac¹,Al-Hroub Haneen¹,Namasivayam Vigneshwaran¹^ORCID,Müller Christa E.¹²^ORCID

Affiliation:

1. PharmaCenter Bonn, Pharmaceutical Institute, Pharmaceutical Sciences Bonn (PSB), Pharmaceutical & Medicinal Chemistry, University of Bonn, 53121 Bonn, Germany

2. Research Training Group 1873, University of Bonn, 53127 Bonn, Germany

Funder

Bundesministerium f?r Bildung und Forschung

Deutscher Akademischer Austauschdienst

Deutsche Forschungsgemeinschaft

Publisher

American Chemical Society (ACS)

Subject

Library and Information Sciences,Computer Science Applications,General Chemical Engineering,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.1c01235

Reference54 articles.

1. G Protein-Coupled Receptors as Targets for Approved Drugs: How Many Targets and How Many Drugs?

2. Ligand binding and activation of UTP-activated G protein-coupled P2Y2 and P2Y4 receptors elucidated by mutagenesis, pharmacological and computational studies

3. Key Determinants of Nucleotide-Activated G Protein-Coupled P2Y2 Receptor Function Revealed by Chemical and Pharmacological Experiments, Mutagenesis and Homology Modeling

4. Structure activity and molecular modeling analyses of ribose- and base-modified uridine 5′-triphosphate analogues at the human P2Y2 and P2Y4 receptors

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