General Purpose 2D and 3D Similarity Approach to Identify hERG Blockers-Reference-Cited by-同舟云学术

General Purpose 2D and 3D Similarity Approach to Identify hERG Blockers

Published:2016-01-08 Issue:1 Volume:56 Page:213-222
ISSN:1549-9596
Container-title:Journal of Chemical Information and Modeling
language:en
Short-container-title:J. Chem. Inf. Model.

Author:

Schyman Patric¹,Liu Ruifeng¹,Wallqvist Anders¹

Affiliation:

1. DoD Biotechnology High Performance Computing Software Applications Institute, Telemedicine and Advanced Technology Research Center, U.S. Army Medical Research and Materiel Command, 2405 Whittier Drive, Frederick, Maryland 21702, United States

Funder

Defense Threat Reduction Agency

U.S. Army Medical Research and Materiel Command

Publisher

American Chemical Society (ACS)

Subject

Library and Information Sciences,Computer Science Applications,General Chemical Engineering,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.5b00616

Reference52 articles.

1. New drugs cost US$2.6 billion to develop

2. hERG potassium channels and cardiac arrhythmia

3. Organising evidence on QT prolongation and occurrence of Torsades de Pointes with non-antiarrhythmic drugs: a call for consensus

4. Collation, assessment and analysis of literaturein vitrodata on hERG receptor blocking potency for subsequent modeling of drugs' cardiotoxic properties

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