The Leu/Val<sup>6.51</sup> Side Chain of Cannabinoid Receptors Regulates the Binding Mode of the Alkyl Chain of Δ<sup>9</sup>-Tetrahydrocannabinol-Reference-Cited by-同舟云学术

The Leu/Val^6.51 Side Chain of Cannabinoid Receptors Regulates the Binding Mode of the Alkyl Chain of Δ⁹-Tetrahydrocannabinol

Published:2023-08-30 Issue:18 Volume:63 Page:5927-5935
ISSN:1549-9596
Container-title:Journal of Chemical Information and Modeling
language:en
Short-container-title:J. Chem. Inf. Model.

Author:

Llinas del Torrent Claudia¹,Raïch Iu²³,Gonzalez Angel¹,Casajuana-Martin Nil¹,Lillo Jaume⁴,Rebassa Joan Biel⁴,Ferreiro-Vera Carlos⁵,Sánchez de Medina Verónica⁵,Franco Rafael²³^ORCID,Navarro Gemma³⁴⁶,Pardo Leonardo¹^ORCID

Affiliation:

1. Laboratory of Computational Medicine, Biostatistics Unit, Faculty of Medicine, Universitat Autònoma Barcelona, 08193 Bellaterra, Barcelona, Spain

2. Department of Biochemistry and Molecular Biomedicine, School of Biology, University of Barcelona, 08028 Barcelona, Spain

3. Centro de Investigación en Red, Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, 28031 Madrid, Spain

4. Department of Biochemistry and Physiology, Faculty of Pharmacy and Food Sciences, Universitat de Barcelona, 08028 Barcelona, Spain

5. Phytoplant Research S.L.U., 14014 Córdoba, Spain

6. Institute of Neuroscience, University of Barcelona (NeuroUB), Av Joan XXIII 27-31, 08028 Barcelona, Spain

Funder

Ministerio de Ciencia e Innovaci?n

European Regional Development Fund

Ministerio de Econom?a y Competitividad

Generalitat de Catalunya

Publisher

American Chemical Society (ACS)

Subject

Library and Information Sciences,Computer Science Applications,General Chemical Engineering,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.3c01054

Reference63 articles.

1. The biosynthesis of the cannabinoids

2. Cannabinoids, Phenolics, Terpenes and Alkaloids of Cannabis

3. Efficacy and Safety of Cannabidiol and Tetrahydrocannabivarin on Glycemic and Lipid Parameters in Patients With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Pilot Study

4. Δ9-Tetrahydrocannabivarin (THCV): a commentary on potential therapeutic benefit for the management of obesity and diabetes

5. The phytocannabinoid, Δ9-tetrahydrocannabivarin, can act through 5-HT1Areceptors to produce antipsychotic effects

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