Successful Identification of Cardiac Troponin Calcium Sensitizers Using a Combination of Virtual Screening and ROC Analysis of Known Troponin C Binders-Reference-Cited by-同舟云学术

Successful Identification of Cardiac Troponin Calcium Sensitizers Using a Combination of Virtual Screening and ROC Analysis of Known Troponin C Binders

Published:2017-11-16 Issue:12 Volume:57 Page:3056-3069
ISSN:1549-9596
Container-title:Journal of Chemical Information and Modeling
language:en
Short-container-title:J. Chem. Inf. Model.

Author:

Aprahamian Melanie L.¹,Tikunova Svetlana B.²,Price Morgan V.²,Cuesta Andres F.²,Davis Jonathan P.²,Lindert Steffen¹^ORCID

Affiliation:

1. Department of Chemistry and Biochemistry, Ohio State University, Columbus, Ohio 43210, United States

2. Davis Heart and Lung Research Institute and Department of Physiology and Cell Biology, Ohio State University, Columbus, Ohio 43210, United States

Funder

National Heart, Lung, and Blood Institute

National Institute on Aging

Publisher

American Chemical Society (ACS)

Subject

Library and Information Sciences,Computer Science Applications,General Chemical Engineering,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.7b00536

Reference90 articles.

1. Tri-modal regulation of cardiac muscle relaxation; intracellular calcium decline, thin filament deactivation, and cross-bridge cycling kinetics

2. Human cardiac troponin complex. Structure and functions

3. Calcium and the heart: a question of life and death

4. Regulation of Contraction in Striated Muscle

5. Cardiac thin filament regulation

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