Discovery of Nanomolar Inhibitors for Human Dihydroorotate Dehydrogenase Using Structure-Based Drug Discovery Methods-Reference-Cited by-同舟云学术

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Discovery of Nanomolar Inhibitors for Human Dihydroorotate Dehydrogenase Using Structure-Based Drug Discovery Methods

Published:2024-01-04 Issue:2 Volume:64 Page:435-448
ISSN:1549-9596
Container-title:Journal of Chemical Information and Modeling
language:en
Short-container-title:J. Chem. Inf. Model.

Author:

Higgins William T.¹,Vibhute Sandip²,Bennett Chad²³,Lindert Steffen¹^ORCID

Affiliation:

1. Department of Chemistry and Biochemistry, Ohio State University, Columbus, Ohio 43210, United States

2. Medicinal Chemistry Shared Resource, Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 43210, United States

3. Drug Development Institute, Ohio State University, Columbus, Ohio 43210, United States

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.3c01358

Reference67 articles.

1. Acute myeloid leukaemia in adults

2. ASLAN003, a potent dihydroorotate dehydrogenase inhibitor for differentiation of acute myeloid leukemia

3. The novel dihydroorotate dehydrogenase (DHODH) inhibitor BAY 2402234 triggers differentiation and is effective in the treatment of myeloid malignancies

4. Pharmacological inhibition of dihydroorotate dehydrogenase induces apoptosis and differentiation in acute myeloid leukemia cells

5. Advances in acute myeloid leukemia

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