In Silico QT and APD Prolongation Assay for Early Screening of Drug-Induced Proarrhythmic Risk-Reference-Cited by-同舟云学术

In Silico QT and APD Prolongation Assay for Early Screening of Drug-Induced Proarrhythmic Risk

Published:2018-03-16 Issue:4 Volume:58 Page:867-878
ISSN:1549-9596
Container-title:Journal of Chemical Information and Modeling
language:en
Short-container-title:J. Chem. Inf. Model.

Author:

Romero Lucia¹,Cano Jordi¹^ORCID,Gomis-Tena Julio¹,Trenor Beatriz¹,Sanz Ferran²,Pastor Manuel²,Saiz Javier¹

Affiliation:

1. Centro de Investigación e Innovación en Bioingeniería (CI2B), Universitat Politècnica de València, camino de Vera, s/n, 46022 Valencia, Spain

2. Research Programme on Biomedical Informatics (GRIB), Institut Hospital del Mar d’Investigacions Mèdiques (IMIM), Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Carrer del Dr. Aiguader 88, 08002 Barcelona, Spain

Funder

Generalitat Valenciana

European Commission

Ministerio de Econom??a y Competitividad

Publisher

American Chemical Society (ACS)

Subject

Library and Information Sciences,Computer Science Applications,General Chemical Engineering,General Chemistry

Link

http://pubs.acs.org/doi/pdf/10.1021/acs.jcim.7b00440

Reference49 articles.

1. Methods of collecting and evaluating non-clinical cardiac electrophysiology data in the pharmaceutical industry: results of an international survey

2. QT prolongation through hERG K+ channel blockade: Current knowledge and strategies for the early prediction during drug development

3. Computational Models of the Heart and Their Use in Assessing the Actions of Drugs

4. Safety and secondary pharmacology: Successes, threats, challenges and opportunities

5. Estimating The Cost Of New Drug Development: Is It Really $802 Million?

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