Discovery of Targeted Covalent Natural Products against PLK1 by Herb-Based Screening-Reference-Cited by-同舟云学术

Discovery of Targeted Covalent Natural Products against PLK1 by Herb-Based Screening

Published:2020-05-14 Issue:9 Volume:60 Page:4350-4358
ISSN:1549-9596
Container-title:Journal of Chemical Information and Modeling
language:en
Short-container-title:J. Chem. Inf. Model.

Author:

Liang Hao¹^ORCID,Liu Hongbo¹,Kuang Yi²,Chen Limin³,Ye Min²^ORCID,Lai Luhua¹³^ORCID

Affiliation:

1. BNLMS, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China

2. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Beijing 100191, China

3. Peking-Tsinghua Center for Life Sciences at Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China

Funder

Ministry of Science and Technology of the People's Republic of China

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

Library and Information Sciences,Computer Science Applications,General Chemical Engineering,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.0c00074

Reference72 articles.

1. The resurgence of covalent drugs

2. Designing Irreversible Inhibitors-Worth the Effort?

3. A road map to evaluate the proteome-wide selectivity of covalent kinase inhibitors

4. Selective irreversible inhibition of a protease by targeting a noncatalytic cysteine

5. The Cysteinome of Protein Kinases as a Target in Drug Development

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