Structure-Based Prediction of hERG-Related Cardiotoxicity: A Benchmark Study-Reference-Cited by-同舟云学术

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Structure-Based Prediction of hERG-Related Cardiotoxicity: A Benchmark Study

Published:2021-09-10 Issue:9 Volume:61 Page:4758-4770
ISSN:1549-9596
Container-title:Journal of Chemical Information and Modeling
language:en
Short-container-title:J. Chem. Inf. Model.

Author:

Creanza Teresa Maria¹,Delre Pietro²³,Ancona Nicola¹^ORCID,Lentini Giovanni⁴,Saviano Michele³^ORCID,Mangiatordi Giuseppe Felice³^ORCID

Affiliation:

1. CNR—Institute of Intelligent Industrial Technologies and Systems for Advanced Manufacturing, Via Amendola 122/o, 70126 Bari, Italy

2. Chemistry Department, University of Bari “Aldo Moro”, via E. Orabona, 4, I-70125 Bari, Italy

3. CNR—Institute of Crystallography, Via Amendola 122/o, 70126 Bari, Italy

4. Department of Pharmacy—Pharmaceutical Sciences, University of Bari “Aldo Moro”, via E. Orabona, 4, I-70125 Bari, Italy

Publisher

American Chemical Society (ACS)

Subject

Library and Information Sciences,Computer Science Applications,General Chemical Engineering,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.1c00744

Reference105 articles.

1. hERG K+Channels: Structure, Function, and Clinical Significance

2. Role of hERG potassium channel assays in drug development

3. Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development

4. Drug-induced QT interval prolongation: mechanisms and clinical management

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