Development of VU6036864: A Triazolopyridine-Based High-Quality Antagonist Tool Compound of the M<sub>5</sub> Muscarinic Acetylcholine Receptor-Reference-Cited by-同舟云学术

Development of VU6036864: A Triazolopyridine-Based High-Quality Antagonist Tool Compound of the M₅ Muscarinic Acetylcholine Receptor

Published:2024-08-06 Issue:16 Volume:67 Page:14394-14413
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Li Jinming¹²,Orsi Douglas L.¹²^ORCID,Engers Julie L.¹²,Long Madeline F.¹²^ORCID,Capstick Rory A.¹²,Maurer Mallory A.¹²,Presley Christopher C.¹²,Vinson Paige N.¹²,Rodriguez Alice L.¹²^ORCID,Han Allie¹²,Cho Hyekyung P.¹²,Chang Sichen¹²,Jackson Megan¹²,Bubser Michael¹²,Blobaum Anna L.¹²,Boutaud Olivier¹²,Nader Michael A.³,Niswender Colleen M.¹²,Conn P. Jeffrey¹²,Jones Carrie K.¹²,Lindsley Craig W.¹^ORCID,Han Changho¹^ORCID

Affiliation:

1. Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States

2. Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States

3. Center for the Neurobiology of Addiction Treatment, Wake Forest School of Medicine, Medical Center Boulevard Winston-Salem, Winston-Salem, North Carolina 27157, United States

Funder

William K. Warren Foundation

Ancora Innovation

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c01193

Reference25 articles.

1. The role of acetylcholine in learning and memory

2. Acetylcholine and cholinergic receptors

3. Targeting Muscarinic Acetylcholine Receptors for the Treatment of Psychiatric and Neurological Disorders

4. Muscarinic Receptors Associated with Cancer

5. Acetylcholine receptors: Key players in cancer development