Impact of PROTAC Linker Plasticity on the Solution Conformations and Dissociation of the Ternary Complex-Reference-Cited by-同舟云学术

Impact of PROTAC Linker Plasticity on the Solution Conformations and Dissociation of the Ternary Complex

Published:2022-01-12 Issue:2 Volume:62 Page:340-349
ISSN:1549-9596
Container-title:Journal of Chemical Information and Modeling
language:en
Short-container-title:J. Chem. Inf. Model.

Author:

Weerakoon Dhanushka¹,Carbajo Rodrigo J.²^ORCID,De Maria Leonardo¹^ORCID,Tyrchan Christian¹^ORCID,Zhao Hongtao¹^ORCID

Affiliation:

1. Medicinal Chemistry, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gothenburg 43183, Sweden

2. Chemistry, Oncology R&D, AstraZeneca, Cambridge CB4 0QA, United Kingdom

Publisher

American Chemical Society (ACS)

Subject

Library and Information Sciences,Computer Science Applications,General Chemical Engineering,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.1c01036

Reference50 articles.

1. Small-Molecule PROTACS: New Approaches to Protein Degradation

2. Drugging the undruggables: exploring the ubiquitin system for drug development

3. Structural basis of lenalidomide-induced CK1α degradation by the CRL4CRBN ubiquitin ligase

4. A novel cereblon modulator recruits GSPT1 to the CRL4CRBN ubiquitin ligase

5. Induced protein degradation: an emerging drug discovery paradigm

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