Interdimeric Curvature in Tubulin–Tubulin Complexes Delineates the Microtubule-Destabilizing Properties of Plocabulin
Author:
Affiliation:
1. Departamento de Ciencias Químicas, Facultad de Ciencias Exactas, Universidad Andres Bello, Sede Concepción, Autopista Concepción-Talcahuano, 7100 Talcahuano, Chile
Funder
Fondo Nacional de Desarrollo Cient?fico y Tecnol?gico
Publisher
American Chemical Society (ACS)
Subject
Library and Information Sciences,Computer Science Applications,General Chemical Engineering,General Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.0c00626
Reference46 articles.
1. Pironetin Binds Covalently to αCys316 and Perturbs a Major Loop and Helix of α-Tubulin to Inhibit Microtubule Formation
2. Tubulin Maytansine Site Binding Ligands and their Applications as MTAs and ADCs for Cancer Therapy
3. Enriching cancer pharmacology with drugs of marine origin
4. Microtubule destabilising agents: far more than just antimitotic anticancer drugs
5. New Interfacial Microtubule Inhibitors of Marine Origin, PM050489/PM060184, with Potent Antitumor Activity and a Distinct Mechanism
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4. Conformers, Properties of the Anticancer Drug Plocabulin, and its Binding Mechanism with p-Glycoprotein: DFT and MD Studies;Australian Journal of Chemistry;2021
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