Probes for Narcotic Receptor Mediated Phenomena. 37. Synthesis and Opioid Binding Affinity of the Final Pair of Oxide-Bridged Phenylmorphans, the Ortho- and Para-b-Isomers and Their N-Phenethyl Analogues, and the Synthesis of the N-Phenethyl Analogues of the Ortho- and Para-d-Isomers-Reference-Cited by-同舟云学术

Probes for Narcotic Receptor Mediated Phenomena. 37. Synthesis and Opioid Binding Affinity of the Final Pair of Oxide-Bridged Phenylmorphans, the Ortho- and Para-b-Isomers and Their N-Phenethyl Analogues, and the Synthesis of the N-Phenethyl Analogues of the Ortho- and Para-d-Isomers

Published:2008-11-18 Issue:24 Volume:51 Page:7866-7881
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kurimura Muneaki¹,Liu Hehua¹,Sulima Agnieszka¹,Hashimoto Akihiro¹,Przybyl Anna K.¹,Ohshima Etsuo¹,Kodato Shinichi¹,Deschamps Jeffrey R.¹,Dersch Christina M.¹,Rothman Richard B.¹,Lee Yong Sok¹,Jacobson Arthur E.¹,Rice Kenner C.¹

Affiliation:

1. Drug Design and Synthesis Section, Chemical Biology Research Branch, National Institute on Drug Abuse and the National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, 5625 Fishers Lane, Room 4N03, Bethesda, Maryland 20892-9415, Clinical Psychopharmacology Section, Chemical Biology Research Branch, National Institute on Drug Abuse, Addiction Research Center, National Institutes of Health, Department of Health and Human Services, Baltimore,...

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm800913d

Reference21 articles.

1. Synthesis and pharmacological effects of the enantiomers of the N-phenethyl analogues of the ortho and para e- and f-oxide-bridged phenylmorphans

2. High-Resolution Crystal Structure of an Engineered Human β 2 -Adrenergic G Protein–Coupled Receptor

3. GPCR Engineering Yields High-Resolution Structural Insights into β 2 -Adrenergic Receptor Function

4. Signaling Across the Cell Membrane

5. Diversifying the repertoire of G protein-coupled receptors through oligomerization

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