1. Department of Food and Nutrition, and Department of Biotechnology, Hungkuang University, 34, Chun-Chie Road, Shalu County, Taichung Hsien 43302, Taiwan, Department of Nursing, Cardinal Tien College of Healthcare and Management, 112, Min-Zu Road, Sin-Dian, Taipei County 23143, Taiwan, and Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan