Impact of pH on Plasma Protein Binding in Equilibrium Dialysis-Reference-Cited by-同舟云学术

Impact of pH on Plasma Protein Binding in Equilibrium Dialysis

Published:2008-03-18 Issue:3 Volume:5 Page:438-448
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Kochansky Christopher J.¹,McMasters Daniel R.¹,Lu Ping¹,Koeplinger Kenneth A.¹,Kerr Haley H.¹,Shou Magang¹,Korzekwa Kenneth R.¹

Affiliation:

1. Department of Drug Metabolism and Pharmacokinetics, Merck Research Laboratories, West Point, Pennsylvania 19486, and Department of Molecular Systems, Merck Research Laboratories, Rahway, New Jersey 07065

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/mp800004s

Reference23 articles.

1. A UNIFIED MODEL FOR PREDICTING HUMAN HEPATIC, METABOLIC CLEARANCE FROM IN VITRO INTRINSIC CLEARANCE DATA IN HEPATOCYTES AND MICROSOMES

2. Prediction of Human Drug Clearance from in Vitro and Preclinical Data Using Physiologically Based and Empirical Approaches

3. Mechanistic Approaches to Volume of Distribution Predictions: Understanding the Processes

4. Evaluation of Human Pharmacokinetics, Therapeutic Dose and Exposure Predictions Using Marketed Oral Drugs

5. Prediction of in vivo drug-drug interactions from in vitro data: impact of incorporating parallel pathways of drug elimination and inhibitor absorption rate constant

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