Discovery of Small Molecule Inhibitors of the PH Domain Leucine-Rich Repeat Protein Phosphatase (PHLPP) by Chemical and Virtual Screening-Reference-Cited by-同舟云学术

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Discovery of Small Molecule Inhibitors of the PH Domain Leucine-Rich Repeat Protein Phosphatase (PHLPP) by Chemical and Virtual Screening

Published:2010-09-13 Issue:19 Volume:53 Page:6899-6911
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Sierecki Emma¹,Sinko William²³,McCammon J. Andrew¹³⁴,Newton Alexandra C.¹

Affiliation:

1. Department of Pharmacology

2. Biomedical Sciences Program

3. Department of Chemistry & Biochemistry and NSF Center for Theoretical Biological Physics

4. Howard Hughes Medical Institute, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm100331d

Reference53 articles.

1. The Phosphoinositide 3-Kinase Pathway

2. Lipid activation of protein kinases

3. AKT/PKB Signaling: Navigating Downstream

4. PTEN: a tumour suppressor that functions as a phospholipid phosphatase

5. Identification of a tumour suppressor network opposing nuclear Akt function

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1. Non-integrin laminin receptor (LamR) plays a role in axonal outgrowth from chicken DRG via modulating the Akt and Erk signaling;Frontiers in Cell and Developmental Biology;2024-07-31

2. Inhibition of Phlpp1 preserves the mechanical integrity of articular cartilage in a murine model of post-traumatic osteoarthritis;Osteoarthritis and Cartilage;2024-06

3. Differential efficacy of two small molecule PHLPP inhibitors to promote nucleus Pulposus cell health;JOR SPINE;2023-12-04

4. Phlpp1 Expression in Osteoblasts Plays a Modest Role in Bone Homeostasis;JBMR Plus;2023-08-28

5. FKBP51 plays an essential role in Akt ubiquitination that requires Hsp90 and PHLPP;Cell Death & Disease;2023-02-13

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