Tuning Morphology in Active Pharmaceutical Ingredients: Controlling the Crystal Habit of Lovastatin through Solvent Choice and Non-Size-Matched Polymer Additives-Reference-Cited by-同舟云学术

Tuning Morphology in Active Pharmaceutical Ingredients: Controlling the Crystal Habit of Lovastatin through Solvent Choice and Non-Size-Matched Polymer Additives

Published:2020-08-04 Issue:9 Volume:20 Page:5854-5862
ISSN:1528-7483
Container-title:Crystal Growth & Design
language:en
Short-container-title:Crystal Growth & Design

Author:

Hatcher Lauren E.¹²,Li Wei³,Payne Pollyanna¹²,Benyahia Brahim³,Rielly Chris D.³,Wilson Chick C.¹²^ORCID

Affiliation:

1. Future Continuous Manufacturing and Advanced Crystallisation (CMAC), Research Hub at the University of Bath, Bath, BA2 7AY, U.K.

2. Department of Chemistry, University of Bath, Bath, BA2 7AY, U.K.

3. Department of Chemical Engineering, Loughborough University, Loughborough, LE11 3TU, U.K.

Funder

Engineering and Physical Sciences Research Council

University of Bath

Publisher

American Chemical Society (ACS)

Subject

Condensed Matter Physics,General Materials Science,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.cgd.0c00470

Reference50 articles.

1. Biosynthesis of the hypocholesterolemic agent mevinolin by Aspergillus terreus. Determination of the origin of carbon, hydrogen, and oxygen atoms by carbon-13 NMR and mass spectrometry

2. Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent.

3. Lovastatin production: From molecular basis to industrial process optimization

4. Total synthesis of (+)-monacolin K (mevinolin)

5. High Expression Level of mok E Enhances the Production of Monacolin K in Monascus

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