Synthesis of Filibuvir. Part III. Development of a Process for the Reductive Coupling of an Aldehyde and a β-Keto-lactone-Reference-Cited by-同舟云学术

Synthesis of Filibuvir. Part III. Development of a Process for the Reductive Coupling of an Aldehyde and a β-Keto-lactone

Published:2013-12-09 Issue:1 Volume:18 Page:45-56
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Ide Nathan D.¹,Ragan John. A.¹,Bellavance Gabriel¹,Brenek Steve J.¹,Cordi Eric M.¹,Jensen Grace O.¹,Jones Kris N.¹,LaFrance Danny¹,Leeman Kyle R.¹,Letendre Leo J.¹,Place David¹,Stanchina Corey L.¹,Sluggett Gregory W.¹,Strohmeyer Holly¹,Blunt Jon²,Meldrum Kevin²,Taylor Stuart²,Byrne Ciaran³,Lynch Denis³,Mullane Sandra³,O’Sullivan Maria M.³,Whelan Marcella³

Affiliation:

1. Chemical Research and Development, ‡Analytical Research and Development, Pfizer Worldwide Research and Development, Eastern Point Road, Groton, 06340 Connecticut

2. Chemical Research & Development, Pfizer Process Development Facility, Ramsgate Road, Sandwich, Kent, U.K.

3. Pfizer Global Supply, Ringaskiddy, Cork County, Ireland

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/op400237j

Reference20 articles.

1. Discovery of (R)-6-Cyclopentyl-6-(2-(2,6-diethylpyridin-4-yl)ethyl)-3-((5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl)-4-hydroxy-5,6-dihydropyran-2-one (PF-00868554) as a Potent and Orally Available Hepatitis C Virus Polymerase Inhibitor

2. Development of a Synthetic Process towards a Hepatitis C Polymerase Inhibitor

3. The selective reduction of .alpha.,.beta.-unsaturated esters, nitriles and nitro compounds with sodium cyanoborohydride

4. Transfer Hydrogenation of Activated CC Bonds Catalyzed by Ruthenium Amido Complexes: Reaction Scope, Limitation, and Enantioselectivity

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