Discovery of (R)-6-Cyclopentyl-6-(2-(2,6-diethylpyridin-4-yl)ethyl)-3-((5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl)-4-hydroxy-5,6-dihydropyran-2-one (PF-00868554) as a Potent and Orally Available Hepatitis C Virus Polymerase Inhibitor-Reference-Cited by-同舟云学术

Discovery of (R)-6-Cyclopentyl-6-(2-(2,6-diethylpyridin-4-yl)ethyl)-3-((5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl)-4-hydroxy-5,6-dihydropyran-2-one (PF-00868554) as a Potent and Orally Available Hepatitis C Virus Polymerase Inhibitor

Published:2009-02-11 Issue:5 Volume:52 Page:1255-1258
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Li Hui¹,Tatlock John¹,Linton Angelica¹,Gonzalez Javier¹,Jewell Tanya¹,Patel Leena¹,Ludlum Sarah¹,Drowns Matthew¹,Rahavendran Sadayappan V.¹,Skor Heather¹,Hunter Robert¹,Shi Stephanie T.¹,Herlihy Koleen J.¹,Parge Hans¹,Hickey Michael¹,Yu Xiu¹,Chau Fannie¹,Nonomiya Jim¹,Lewis Cristina¹

Affiliation:

1. Pfizer Global Research and Development, La Jolla Laboratories, 10770 Science Center Drive, San Diego, California 92121

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm8014537

Reference22 articles.

1. Hepatitis C

2. The way forward in HCV treatment — finding the right path

3. R1626 plus peginterferon Alfa-2a provides potent suppression of hepatitis C virus RNA and significant antiviral synergy in combination with ribavirin

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