Sequence-Specific Trapping of Topoisomerase I by DNA Binding Polyamide−Camptothecin Conjugates
Author:
Affiliation:
1. Contribution from the Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125
Publisher
American Chemical Society (ACS)
Subject
Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis
Link
https://pubs.acs.org/doi/pdf/10.1021/ja010392p
Reference23 articles.
1. Regulation of gene expression by small molecules
2. Inhibition of RNA polymerase II transcription in human cells by synthetic DNA-binding ligands
3. Sequence-specific DNA recognition by polyamides
4. Mechanism of action of eukaryotic DNA topoisomerase I and drugs targeted to the enzyme
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