Novel Syntheses of 2-Butyl-5-chloro-3H-imidazole-4-carbaldehyde: A Key Intermediate for the Synthesis of the Angiotensin II Antagonist Losartan
Author:
Affiliation:
1. Lonza AG, Walliser Werke, CH-3930 Visp, Switzerland
2. Cerecon AG, Hauptstrasse 144, CH-4416, Bubendorf, Switzerland
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/jo9824910
Reference18 articles.
1. Efficient Synthesis of Losartan, A Nonpeptide Angiotensin II Receptor Antagonist
2. Nonpeptide angiotensin II receptor antagonists: the discovery of a series of N-(biphenylylmethyl)imidazoles as potent, orally active antihypertensives
3. A Practical Synthesis of 2-Butyl-4(5)-chloro-5(4)-hydroxymethyl- 1H-imidazole
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