Optimization of High-Throughput Methyltransferase Assays for the Discovery of Small Molecule Inhibitors-Reference-Cited by-同舟云学术

Optimization of High-Throughput Methyltransferase Assays for the Discovery of Small Molecule Inhibitors

Published:2020-06-11 Issue:8 Volume:22 Page:422-432
ISSN:2156-8952
Container-title:ACS Combinatorial Science
language:en
Short-container-title:ACS Comb. Sci.

Author:

Dong Guangping¹²,Yasgar Adam³^ORCID,Peterson Darrell L.⁴,Zakharov Alexey³^ORCID,Talley Daniel³,Cheng Ken Chih-Chien³,Jadhav Ajit³,Simeonov Anton³,Huang Rong¹²^ORCID

Affiliation:

1. Department of Medicinal Chemistry and Molecular Pharmacology, Center for Cancer Research, Institute for Drug Discovery, Purdue University, West Lafayette, Indiana 47907, United States

2. Department of Medicinal Chemistry, Institute for Structural Biology, Drug Discovery and Development, Virginia Commonwealth University, Richmond, Virginia 23219, United States

3. National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20892, United States

4. Department of Biochemistry, Institute for Structural Biology, Drug Discovery and Development, Virginia Commonwealth University, Richmond, Virginia 23219, United States

Funder

National Cancer Institute

Publisher

American Chemical Society (ACS)

Subject

General Chemistry,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acscombsci.0c00077

Reference42 articles.

1. Chemical Inhibition of Protein Methyltransferases

2. Dysregulation of de novo nucleotide biosynthetic pathway enzymes in cancer and targeting opportunities

3. A Phase 1 Study of the DOT1L Inhibitor, Pinometostat (EPZ-5676), in Adults with Relapsed or Refractory Leukemia: Safety, Clinical Activity, Exposure and Target Inhibition