Comparative Study of Adenosine Analogs as Inhibitors of Protein Arginine Methyltransferases and a Clostridioides difficile-Specific DNA Adenine Methyltransferase

Author:

Zhou Jujun1,Deng Youchao2,Iyamu Iredia D.2,Horton John R.1,Yu Dan1,Hajian Taraneh3,Vedadi Masoud43ORCID,Rotili Dante5ORCID,Mai Antonello56ORCID,Blumenthal Robert M.7,Zhang Xing1,Huang Rong2ORCID,Cheng Xiaodong1ORCID

Affiliation:

1. Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, United States

2. Department of Medicinal Chemistry and Molecular Pharmacology, Institute for Drug Discovery, Center for Cancer Research, Purdue University, West Lafayette, Indiana 47907, United States

3. Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada

4. Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON M5S 1A8, Canada

5. Department of Drug Chemistry and Technologies, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy

6. Pasteur Institute, Cenci-Bolognetti Foundation, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy

7. Department of Medical Microbiology and Immunology and Program in Bioinformatics, The University of Toledo College of Medicine and Life Sciences, Toledo, Ohio 43614, United States

Funder

Ministero dell’Istruzione, dell’Università e della Ricerca

Sapienza Università di Roma

Cancer Prevention and Research Institute of Texas

National Institute of General Medical Sciences

Ralph W. and Grace M. Showalter Research Trust Fund

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

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