Synthesis and Structure–Activity Relationship Studies of 4-((2-Hydroxy-3-methoxybenzyl)amino)benzenesulfonamide Derivatives as Potent and Selective Inhibitors of 12-Lipoxygenase-Reference-Cited by-同舟云学术

Synthesis and Structure–Activity Relationship Studies of 4-((2-Hydroxy-3-methoxybenzyl)amino)benzenesulfonamide Derivatives as Potent and Selective Inhibitors of 12-Lipoxygenase

Published:2014-01-06 Issue:2 Volume:57 Page:495-506
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Luci Diane K.¹,Jameson J. Brian²,Yasgar Adam¹,Diaz Giovanni²,Joshi Netra²,Kantz Auric²,Markham Kate²,Perry Steve²,Kuhn Norine³,Yeung Jennifer⁴,Kerns Edward H.¹,Schultz Lena¹,Holinstat Michael⁴,Nadler Jerry L.³,Taylor-Fishwick David A.³,Jadhav Ajit¹,Simeonov Anton¹,Holman Theodore R.²,Maloney David J.¹

Affiliation:

1. National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, United States

2. Department of Chemistry and Biochemistry, University of California, Santa Cruz, California, United States

3. Strelitz Diabetes Center, Eastern Virginia Medical School, Norfolk, Virginia, United States

4. Department of Medicine, Cardeza Foundation for Hematologic Research, Thomas Jefferson University, Philadelphia, Pennsylvania, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm4016476

Reference68 articles.

1. New insights from spectroscopy into the structure/function relationships of lipoxygenases

2. Lipoxygenases: Occurrence, Functions, Catalysis, and Acquisition of Substrate

3. Resolvins and Protectins in Inflammation Resolution

4. Inhibition of arachidonate 5-lipoxygenase triggers prostate cancer cell death through rapid activation of c-Jun N-terminal kinase

5. Inhibition of arachidonate 5-lipoxygenase triggers massive apoptosis in human prostate cancer cells

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