Computer-Aided Design, Synthesis, and Anti-HIV-1 Activity in Vitro of 2-Alkylamino-6-[1-(2,6-difluorophenyl)alkyl]-3,4-dihydro-5-alkylpyrimidin-4(3H)- ones as Novel Potent Non-Nucleoside Reverse Transcriptase Inhibitors, Also Active Against the Y181C Variant-Reference-Cited by-同舟云学术

Computer-Aided Design, Synthesis, and Anti-HIV-1 Activity in Vitro of 2-Alkylamino-6-[1-(2,6-difluorophenyl)alkyl]-3,4-dihydro-5-alkylpyrimidin-4(3H)- ones as Novel Potent Non-Nucleoside Reverse Transcriptase Inhibitors, Also Active Against the Y181C Variant

Published:2004-01-08 Issue:4 Volume:47 Page:928-934
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Ragno Rino¹,Mai Antonello¹,Sbardella Gianluca¹,Artico Marino¹,Massa Silvio¹,Musiu Chiara¹,Mura Massimo¹,Marturana Flavia¹,Cadeddu Alessandra¹,La Colla Paolo¹

Affiliation:

1. Dipartimento di Studi di Chimica e Tecnologie delle Sostanze Biologicamente Attive, Università degli Studi di Roma “La Sapienza”, P.le A. Moro 5, I-00185 Roma, Italy, Istituto Pasteur-Fondazione Cenci Bolognetti, Dipartimento di Studi Farmaceutici, Università degli Studi di Roma “La Sapienza”, P.le A. Moro 5, I-00185 Roma, Italy, Dipartimento di Scienze Farmaceutiche, Università degli Studi di Salerno, Via Ponte Don Melillo, I-84084 Fisciano (SA), Italy, Dipartimento Farmaco Chimico Tecnologico,...

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm0309856

Reference41 articles.

1. In Vivo Activity Against HIV and Favorable Toxicity Profile of 2′,3′-Dideoxyinosine

2. Resistance of clinical isolates of human immunodeficiency virus to antiretroviral agents

3. Non-Nucleoside Reverse Transcriptase Inhibitors: The NNRTI Boom

4. Nonnucleoside reverse transcriptase inhibitors

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